Cisplatin nmr
WebAug 6, 2015 · Cisplatin rapidly accumulates in mitochondria and deteriorates the mitochondrial structure and metabolic function [ 13 ]. This leads to significant changes in the metabolites level related to the tricarboxylic acid cycle (TCA cycle) and glycolysis pathway [ … Antitumor agent cisplatin1 and its derivatives,2,3 when used alone or in combination with other chemotherapeutics4,5 can be effective against the advancement of several clinical cases of cancer. However, there are several known factors such as low selectivity, resistance and consequently, high toxicity that are … See more The calculations were carried out using the GAUSSIAN 09 package.34 The methodology used for the prediction of the NMR chemical shifts … See more In this work we used the relativistic NMR-DKH basis sets for the calculation of the 1H, 15N and 195Pt NMR spectra of inclusion complexes formed between cisplatin and … See more In this work we re-optimize the geometries of the molecular models of cDDP@CNTox or complex I (C168H24O15Cl2N2Pt) and cDDP@CNCox or … See more L. A. De Souza thanks the CAPES for a Post-Doctoral scholarship (Proc. No. 88882.306139/2024-01) during the period 2024–2024 at Universidade Federal Fluminense and support provided by Professor J. C. … See more
Cisplatin nmr
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WebFeb 1, 2012 · Cisplatin, 1, was used as purchased (Sigma-Aldrich, St. Louis, MO). Stock solutions of the platinum compounds in distilled water, 1 and 3, or DPBS (Dulbecco's phosphate buffered saline) buffer, 4, were in the range of 40–650 μM. WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …
WebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... WebFeb 18, 2024 · Furthermore, in order to elucidate the host-guest chemistry of the metallacages and the factors that favor cisplatin's retention in the supramolecular complexes, essential aspects to exploit the cages as drug delivery systems, the drug encapsulation was studied by 1 H, 1 H DOSY, and 195 Pt NMR spectroscopy under …
WebMay 1, 2024 · Geometries and NMR properties of cisplatin and transplatin revisited at the four-component relativistic level. The equilibrium structures of cisplatin and transplatin … WebOct 16, 2013 · To monitor cisplatin-induced cell killing, a cell viability assay using ATPlite 1 Step kit (Perkin Elmer) was performed according to the manufacturer’s instructions followed by luminescence measurement …
WebOct 5, 2004 · NMR techniques sensitive to lipid organization, 31 P NMR and 2 H NMR, revealed that the cisplatin core is coated by phospholipids in a bilayer configuration and that the interaction between solid core and bilayer coat exerts a strong ordering effect on the phospholipid molecules. Compared to phospholipids in liposomal membranes, the …
WebApr 9, 1999 · NMR studies of the activation of cisplatin and related complexes, DNA platination, reactions with amino acids, peptides and proteins are discussed in this … how is beach nourishment doneWebDec 1, 2024 · Cisplatin and CasIIgly treatment had different effects on tumor cell metabolism. Cisplatin mainly affected phospholipid biosynthesis at the times established … how is beach glass madeWebMay 1, 2024 · The equilibrium structures of cisplatin and transplatin were optimized, and their 1 H, 15 N, and 195 Pt NMR chemical shifts were evaluated at both non-relativistic and fully relativistic four-component levels. Reliable correlations with experimental data were achieved at the DFT level with taking into account relativistic effects in calculations of … how is beach glass formedWebIt has been shown that the WP04 functional in combination with moderate basic sets 6-31G(d) and SDD allows to calculate characteristics of 1H NMR-spectrum of metal complexes with ligands based on tetrazole derivatives with high accuracy, which can be highland battery specialists plus golf carsWebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … highland battery assessment loginWebOct 22, 2024 · In NMR analysis, the effect of C. nutans aqueous extract against cisplatin on NRK-52E was quantitatively determined relative to the concentration of the internal reference standard, trimethylsilyl propionic acid (TSP). The concentration of the metabolites in NRK-52E cells extract and culture media of treated and non-treated groups and their ... how is bead size measuredWebThe paper gives an overview of the basic NMR techniques particularly relevant for studying interaction between platinum compounds and nucleic acid constituents. The latest NMR … how is beach volleyball scored