WebODN M362, a class C oligodeoxynucleotide, is a TLR-9 agonist and can be used as a vaccine adjuvant. ODN M362 induces cancer cell apoptosis. - Mechanism of Action & … WebIn this study, we demonstrated that CpG M362 (CpG-C ODN) as an adjuvant in anti-HBV vaccine (cHBV-vaccine) successfully and safely eliminated the virus in HBV-carrier mice. The cHBV-vaccine enhanced DC maturation both in vivoand in vitro, overcame immune tolerance, and recovered exhausted T cells in HBV-carrier mice.
ODN M362 : TLR9 Agonist - Stimulatory CpG ODN, Class C
WebMar 3, 2011 · 3.4. Competitively binding with TLR9. Both types of cells were treated with 1 μM of the 6FAM-labeled optimal stimulatory CpG-ODN 1826, 2216 or M362, and supplemented respectively with Cy3-labeled CpG-ODN c41 respectively at a concentration of 0.5 μM, 1 μM or 2 μM.After incubating for 15 min and fixing with 4% paraformaldehyde … WebODN M362 is a type C human/murine TLR9 agonist. It displays both high induction of PDC and activation of B cells. Class C of ODN combines features of both types A and B, they induce strong IFN-α production from DC and B cell stimulation. Sequence. 5'-tcgtcgtcgttcgaacgacgttgat-3' (25 mer) how was safety glass invented
In vivo immune stimulation by a P-Class CpG ODN. (A–C
WebJan 23, 2014 · Interestingly, ODN M362 and ODN M362 Ctrl displayed a similar proapoptotic effect on HCC, possibly related to phosphorothioate modification of the structure of CpG ODN. Although both of them resulted in the upregulation of the TLR9 receptor, their effect on HCC apoptosis was independent of TLR9. WebJan 23, 2014 · 209 A class C CpG-ODN, YW002 ... HepG2 and H7402 cells from human HCC cell lines were transfected with CpG ODNs (TLR9 agonist ODN M362 and its negative control ODN M362 ctrl) or small interfering ... WebJan 1, 2024 · In this study, we demonstrated that CpG M362 (CpG-C ODN) as an adjuvant in anti-HBV vaccine (cHBV-vaccine) successfully and safely eliminated the virus in HBV … how was sahara desert formed