WebCT-2103 (XYOTAX, Cell Therapeutics, Inc.) is a conjugate of paclitaxel to a polyglutamate polymer. Its macromolecular nature exploits enhanced permeability and retention in … WebThese data describing the preclinical and early clinical development of CT-2103 demonstrate the feasibility of using polyglutamic acid homopolymers to create …
Phase II Study of CT2103 in Patients With Recurrent
WebJun 11, 2009 · Purpose: The primary objective of this study was to determine the maximum tolerated dose (MTD) of CT-2103 (poly L-glutamic acid-paclitaxel) in combination with carboplatin in patients with histologically proven solid tumors that were either refractory to conventional treatment or for which no conventional therapy was available.Patients and … WebJun 1, 2008 · Treatment Completion Rates. The median number of cycles was four in each arm. In the PPX arm, 27% of patients completed six cycles of therapy compared with 36% in the paclitaxel arm (p = 0.0411; Fisher's exact test).The most frequent reasons for stopping treatment were PD (36% versus 34%, respectively) and adverse effects (27% versus … covey michael
Phase III Trial Comparing Paclitaxel Poliglumex (CT-2103, PPX) in ...
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