Enzymatic assembly of the salinosporamide
WebSep 4, 2024 · Salinosporamide A is characterized by a complex and densely functionalized γ-lactam-β-lactone bicyclic warhead, the assembly of which has long remained a … WebMar 21, 2024 · Researchers at UC San Diego's Scripps Institution of Oceanography found that an enzyme called SalC assembles what the team calls the salinosporamide anti …
Enzymatic assembly of the salinosporamide
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WebJan 23, 2007 · Salinosporamide I (13), in which the methyl group at the ring junction is replaced with an ethyl group, and the C-5 deshydroxyl analogue salinosporamide J (14), were also identified. Replacement of synthetic sea salt with sodium bromide in the fermentation media produced bromosalinosporamide (12), 4, and its C-2 epimer (11, … WebMar 22, 2024 · Researchers at UC San Diego's Scripps Institution of Oceanography found that an enzyme called SalC assembles what the team calls the salinosporamide anti …
WebJul 28, 2009 · Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-l-methionine. Polyketides are among … WebSalinosporamide is another more potent proteasome inhibitor that was isolated by Fenical et al. from the marine microorganism, which is widely distributed in ocean sediments. …
WebA full account of concise, enantioselective syntheses of the anticancer agent (−)-salinosporamide A and derivatives, including (−)-homosalinosporamide, that was … WebEnzymatic assembly of the salinosporamide γ-lactam-β-lactone anticancer warhead. Bauman KD et al. Nature Chemical Biology. 2024 05; 18(5):538-546 ... The whole work unveiled the machinery of bicyclization in the biosynthesis of the anti-cancer drug candidate, salinosporamide A, by characterizing SalC’s dual function of aldol and ...
WebMar 21, 2024 · Salinosporamide A is characterized by a complex and densely functionalized γ-lactam-β-lactone bicyclic warhead, the assembly of which has long … We would like to show you a description here but the site won’t allow us.
WebMar 21, 2024 · a, salinosporamide biosynthetic gene cluster (sal BGC) and proposed bicyclization of the SalB-PCP-tethered linear intermediate to assemble the … systemvariablen setzen windows 10WebMay 4, 2007 · The β-lactone in these systems and the chloro-substituent in salinosporamide precursors is shown to be tolerant to several transformations which contributes to the brevity of the sequence. 1c The described bis-cyclization process points to a logical ... Enzymatic assembly of the salinosporamide γ-lactam-β-lactone … systemverilog always latchWebJul 28, 2009 · We recently reported that chlorine incorporation into salinosporamide A is catalyzed by the SAM-dependent chlorinase SalL in an orthogonal manner to other known enzymatic chlorination reactions, but analogous to fluorinase FlA of Streptomyces cattleya, a fluoroacetate and 4-fluorothreonine producer ( 11, 21 ). systemverilog array of struct initializationWeb2 days ago · A team of researchers from Leipzig University has discovered how an enzyme that can break down PET works, and has further increased the efficiency of this biocatalyst. The scientists report their ... systemverilog array of interfaceWebMar 21, 2024 · Scientists now for the first time understand the enzyme-driven process that activates the molecule. Researchers at UC San Diego’s Scripps Institution of … systemtyp windows 11 feststellenWebWe construct peptide-nanoparticle conjugates (AuNP@CDs-Azo-peptide) by self-assembly of cyclodextrin capped gold nanoparticles (AuNP@CDs) and azobenzene terminated peptide (Azo-peptide) through host-guest interaction. AuNP@CDs-Azo-peptide has hydrolase-like activity, which is tuned by amino acid sequences. systemvariabler windows 11WebMar 22, 2024 · It starts as a linear molecule that folds into a more complex circular shape. “Salinosporamide A is characterized by a complex and densely functionalized γ-lactam … systemverilog array initialization