Klf4 chip

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August undefined, 2024

WebKLF4 belongs to the KLF family of transcription factors that regulate several cell functions. It is highly expressed in differentiated epithelial cells of the … WebFeb 25, 2013 · Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8) We have identified the zinc-finger transcription factor Kruppel-like factor 4 (Klf4) …

KLF4 Antibody (NBP1-83940): Novus Biologicals

WebApr 10, 2024 · 然而，在老化的组织中，这种允许去分化和再分化的可塑性能力降低，这一缺陷可以通过转录因子oct4、sox2、klf4和myc（oskm）的瞬时转基因表达将成体细胞转化为胚胎多能细胞（称为诱导多能干细胞或ipscs）来修复，并提高受损老化组织的修复能力，如 … WebOct 14, 2024 · KLF4 was reported as a critical transcription factor (TF) in maintaining endothelial cell homeostasis. As a key transcriptional co-activator, MED1 binds to KLF4 to regulate cell proliferation, differentiation, and apoptosis, as well as somatic cell reprogramming. spa chatelet orleans

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WebKLF4 is important in cell-cycle control, cellular differentiation, and carcinogenesis (53–55). We then compared published KLF4 ChIP-seq peaks ( 56 ) with eRNAs and found that KLF4 binding was enriched in eRNA … WebAug 30, 2007 · KLF4 induces a monocytic phenotype in HL-60 cells To determine whether KLF4 participates directly in monocytic differentiation, we retrovirally infected HL-60 cells with either full-length KLF4 or an empty virus control (EV) and analyzed the cells for various myeloid markers 4 days later. WebMar 21, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Epilepsy, Idiopathic Generalized 15 and Familial Adenomatous Polyposis . Among its related pathways are … teamsters media hub

KLF4 regulates TERT expression in alveolar epithelial cells in

Anti-KLF4 antibody (ab129473) Abcam

WebAnti-KLF4, Cat. No. ABE2860, is a highly specific rabbit polyclonal antibody that targets Krueppel-like factor 4 (Klf4) and has been tested for use in ChIP-seq, Chromatin Immunoprecipitation (ChIP), Immunoprecipitation, and Western Blotting. - Find MSDS or SDS, a COA, data sheets and more information. WebSep 3, 2013 · Furthermore, KLF4 binds specific methylated or unmethylated motifs in human embryonic stem cells in vivo. Our study suggests that mCpG-dependent TF binding activity is a widespread phenomenon and … teamsters national benefit planhttp://homer.ucsd.edu/homer/workshops/170209-MED263/index.html teamsters national

"WebKLF4 belongs to the Kruppel-like factor (KLF) family, a group of conserved zinc finger TFs that regulates essential biological processes such as proliferation and development. Reflecting pioneer factor activity, KLF4 uses two out of its three zinc fingers to target a GC-rich hexameric motif enriched within nucleosomal targets22 ( Fig. 7.2 C). " - Klf4 chip

Klf4 chip

Roles of KLF4 and AMPK in the inhibition of glycolysis …

WebAntibodies that detect KLF4 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. … WebFeb 17, 2024 · KLF4 is a transcription factor that is widely present in eukaryotic cells with zinc finger structures and can promote cancer or tumour suppressors in different types of tumours. A large number of researchers have studied the …

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WebJun 13, 2011 · KLF4 is essential for IL-4–mediated macrophage M2 polarization. ( A) Impairment of M2 marker gene expression in KLF4-deficient macrophages. PMs isolated from Mye-WT and Mye-KO mice were treated with IL-4 for 16 hours. n = 3 in each group. ( B) KLF4 overexpression enhances M2 gene expression.

WebMar 7, 2013 · The ChIP-seq data at the Klf4 gene locus revealed a distal region with multiple IRF8 ChIP-seq peaks spanning 120 kb (208 to 328 kb upstream of the Klf4 TSS) (Figure 3A and supplemental Figure 2). Each IRF8 ChIP-seq peak contained composite elements for IRF and ETS. Importantly, this region was tightly associated with high levels of the H3K4me1 ... KLF4 interacts with the SWI/SNF nucleosome remodeling complex to increase chromatin accessibility Having established that loss of KLF reduces chromatin accessibility, we next sought to identify a...

WebJul 30, 2024 · A commercial ChIP-grade anti-KLF4 antibody (H180; Santa Cruz) recognizing the N-terminal region of KLF4 was used for ChIP (DNA-binding domains of KLF4 are located to the C-terminus). Tet-on KLF4 WT and R458A cells were treated with Dox for 48 h followed by ChIP using the anti-KLF4 antibody and Dynabeads Protein A/G (Thermo Fisher … WebFeb 28, 2024 · GEO help: Mouse over screen elements for information. ChIP-nexus data for Oct4, Sox2, Nanog and Klf4 in mouse embryonic stem cells. The goal of this study was discover the transcription binding synthax for the key differentiation TFs in mouse embryonic stem cells. Genes are regulated through enhancer sequences, in which …

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WebDec 7, 2024 · In combination with KLF4-ChIP seq data, we observed KLF4 binding enrichment at transcription start sites (TSSs) of more than 50% of genes that were significantly changed in NPCs compared with ESCs (fold-change ≥ 2 or ≤–2, P < 0.05) (Figure 1A), as well as at about 80% of gene bodies (Figure 1A), suggesting a possible KLF4 … teamsters national pipeline training fundWebMay 4, 2024 · Furthermore, ChIP showed that KLF4 protein could bind to the TERT promoter region in MLE-12 cells, suggesting that KLF4 could implicate in pathogenesis of lung fibrosis through regulating TERT transcription in AECs. teamsters near meWebGet better batch-to-batch reproducibility with a recombinant antibody. Anti-KLF4 antibody [EPR20753-25] (ab214666) Research with confidence – consistent and reproducible results with every batch. Long-term and … s p a chatellereautlWebFeb 17, 2024 · Kruppel-like factor 4 (KLF4) is a zinc finger-containing transcription factor predominantly expressed in terminally differentiated epithelial tissues. Many studies have … spa chat bordeauxWebApr 1, 2024 · Results of in vivo KLF4 ChIP-Seq analyses, and studies in cultured SMC treated with cholesterol identified > 800 KLF4 target genes including many that regulate pro-inflammatory responses of SMC. Results indicate that the contribution of SMCs within atherosclerotic plaques has been greatly underestimated, and that KLF4-dependent … spa chateaubourg chien a adopterWebklf4-esc.chr17.2m.sam oct4-esc.chr17.2m.sam sox2-esc.chr17.2m.sam These files are originally from the following study investigating the roles that reprogramming factors play when transforming MEF (fibroblasts) into embryonic stem cells. Chronis et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming teamsters ncWebKLF4 Antibodies Antibodies that detect KLF4 can be used in several scientific applications, including Western Blot, Immunocytochemistry, Immunohistochemistry, ELISA and Immunoprecipitation. These antibodies target KLF4 in Human, Mouse, Rat and Non-human primate samples. spa chatham nj