NettetAmong the many species capable of these behaviors are laboratory mice, which when fasted for as few as six to ten hours enter torpor – a state of decreased metabolic rate, locomotion, and body temperature as low as 20°C. We wondered how the brain controls mouse torpor and if we could find neurons which, when stimulated, would induce torpor. NettetPlus a group of mice will snuggle in a hide together and stay warm. My house is at 69 and I gave my 3 girls some fleece scraps and extra nesting material for added warmth, they didn't show any sign of torpor but they did get the sniffles.

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Nettet6. feb. 2024 · White mice are ubiquitous laboratory animals and have been extensively studied. To reveal potential undiscovered traits, we tested the hypothesis that during development, when heat loss in mouse pups is high, they can use daily torpor for energy conservation. We determined at what age individual mouse pups are able to defend … NettetClearly, the various torpor-active neurons described in this review, whose activation leads to a deep and prolonged hypothermia similar to that during mouse torpor, would be … don meyler inspection

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Nettet6. jul. 2024 · Recent studies have shown that the median preoptic area contains a population of neurons expressing an array of fast neurotransmitters and receptors that collectively cause a fall in body temperature in response to environmental warming or depleted energy stores. In this issue of Cell Metabolism, Piñol et al., 2024. NettetSpecifically, we focus on investigating: 1) how the brain regulates torpor (in mice) and hibernation (in hamsters), 2) how cells and genomes of different organisms adapt to these states, and 3) whether inducing these states can slow down tissue damage, disease progression, and even aging. Our long-term goal is to explore potential applications ... Nettet11. jun. 2024 · Single-cell RNA analysis of the torpor-activated neurons showed that the largest subset of such cells were those expressing the gene for pituitary adenylate cyclase-activating polypeptide (PACAP). Subsequent experiments in which only these PACAP-positive cells were activated in mice showed a similar induction of torpor. don michael field hutchinson ks